tag:blogger.com,1999:blog-14815894.post486446883092019019..comments2024-03-18T10:22:55.986-04:00Comments on Bayblab: Cancer Vaccine Clinical TrialsKamelhttp://www.blogger.com/profile/15548259062576527751noreply@blogger.comBlogger4125tag:blogger.com,1999:blog-14815894.post-46925340357619961312009-09-03T11:22:42.640-04:002009-09-03T11:22:42.640-04:00Vaccination with a self peptide to eliminate estab...<em>Vaccination with a self peptide to eliminate established disease? Good luck with that...</em><br /><br />I didn't look closely but I'd be amazed if the vaccine was the sole component of the therapy. I would expect that it's an adjunct therapy on top of the usual chemo, and the goal would be to enhance clearance and reduce the recurrence rate -- makes specially good sense if chemo does in fact work by triggering immune responses to cancer antigens (as has been proposed by a couple of groups recently).Ianhttp://www.iayork.com/MysteryRaysnoreply@blogger.comtag:blogger.com,1999:blog-14815894.post-62692881115230846522009-09-02T16:04:50.456-04:002009-09-02T16:04:50.456-04:00Yes, that's true it has been tested before (th...Yes, that's true it has been tested before (this is even mentioned in the press release). My understanding was that those were early-phase, but looking at clinicaltrials.gov that seems to not be the case - Phase II trials of a NY-ESO-1 based vaccine took place in Australia and the UK a few years ago.<br /><br />So you're right, this is probably more a case of hyping their production facility than anything.Kamelhttps://www.blogger.com/profile/15548259062576527751noreply@blogger.comtag:blogger.com,1999:blog-14815894.post-11477507837485937662009-09-02T16:00:54.094-04:002009-09-02T16:00:54.094-04:00Vaccination with a self peptide to eliminate estab...Vaccination with a self peptide to eliminate established disease? Good luck with that...<br /><br />I thought the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?orig_db=PubMed&db=pubmed&cmd=Search&term=%22Nature%20biotechnology%22%5BJour%5D%20AND%2023%5Bvolume%5D%20AND%20349%5Bpage%5D" rel="nofollow">artificial TCR against NY-ESO-1</a> sounded pretty good. A MILLION times higher affinity for antigen than natural T cells???? That's gotta be good for something, if only just immunological castration...Baymanhttps://www.blogger.com/profile/03436172198266062229noreply@blogger.comtag:blogger.com,1999:blog-14815894.post-7593969470383527312009-09-02T14:17:52.773-04:002009-09-02T14:17:52.773-04:00Just as a point of reference, clinicaltrials.gov r...Just as a point of reference, clinicaltrials.gov returns 917 results for "cancer AND vaccine"; 201 for "vaccine AND melanoma"; 28 for "vaccine AND NY-ESO-1". I don't think there's anything particularly ground-breaking about this particular trial.iayorkhttp://www.iayork.com/MysteryRaysnoreply@blogger.com