tag:blogger.com,1999:blog-14815894.post1215918346877787753..comments2024-03-27T06:52:45.545-04:00Comments on Bayblab: Local Science: Caspase Activation and DifferentiationKamelhttp://www.blogger.com/profile/15548259062576527751noreply@blogger.comBlogger3125tag:blogger.com,1999:blog-14815894.post-46061833319437155132010-02-18T13:23:35.967-05:002010-02-18T13:23:35.967-05:00Ed Yong is pretty awesome.
Same here I have heard ...Ed Yong is pretty awesome.<br />Same here I have heard about this stuff for years now and wondered if I would ever see it published.<br />I don't see there being a cancer problem. Sure the differentiated muscle cells will possibly be rendered insensitive to death signals but I don't see them replicating with lots of DNA damage. Perhaps they are rendered more sensitive to apoptosis as well.<br />Pretty neat stuff. AC you should have sent him some of your caspase 3 westerns from your Leydig cells. PNAS isn't too shabby.Robhttps://www.blogger.com/profile/11878582460269426199noreply@blogger.comtag:blogger.com,1999:blog-14815894.post-15183790066055836862010-02-16T13:58:02.848-05:002010-02-16T13:58:02.848-05:00It seems like it's only cut in particular spot...It seems like it's only cut in particular spots in the differentiation process and not widespread slice and dice. They suspect that may be due to DNA conformation. I suppose it's one way to tightly regulate a well-orchestrated process: if the cell screws up these precise cuts, it enters full blown apoptosis? <br /><br />It does pose some interesting conundrums as you point out - would targeted differentiation in this manner have some weird side effects? What about therapies that target apoptotic processes?Kamelhttps://www.blogger.com/profile/15548259062576527751noreply@blogger.comtag:blogger.com,1999:blog-14815894.post-82501195496856113872010-02-16T13:30:13.506-05:002010-02-16T13:30:13.506-05:00Haven't read the study yet but I've seen h...Haven't read the study yet but I've seen his stuff before... It wasn't clear to me how the DNA can be dammaged, and caspase 3 activated but the cells don't die. Seems like a dangerous strategy to damage your own DNA and become insensitive to death signals from a cancer standpoint. That being said I've noticed my Leydig cells activate caspase 3 when they differentiate, i was just never sure if it was a weeding out process or if they eventually recover from it...Anonymous Cowardhttps://www.blogger.com/profile/13315733940344340689noreply@blogger.com