A while back I did a journal club about microRNAs predicted to be expressed by viruses. Pretty much all of it was computational prediction. A new Nature paper
(link to summary) shows that HSV-1 inhibits neuronal death during a latent infection through a microRNA mechansim inhibiting TGF-B and SMAD3 validating my journal club as worthwhile. These genes are central targets but the paper points to a great unbiased approach to find key genes. Viral microRNAs must have evolved to target some pretty important genes. Interesting to see what will be next.
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