Tuesday, November 20, 2007

Ethical "Embryonic" Stem Cells from Your Skin

First it was mouse fibroblasts, and now human dermal fibroblasts have been reprogrammed to have pluripotent ES-like potential. Again, as in murine cells, ectopic expression of the fantastic transcription factor foursome of c-myc, Sox4, Klf4, and Oct3/4 will do the trick. Alternatively, Klf4 and c-myc can be substituted with Nanog and Lin28. Either way it's personalized stem cells from your skin. I'm going to get to work on mine right now...


4 comments:

Ricardo Vidal said...

I'm sorry, did you say totipotency? I though pluripotency was as far as it went.
It's a specific, but there is a difference.

Bayman said...

ok, ok you're right. my mistake.

geez. why the fuss about engineered cell culture artifacts anyway?

Lim Leng Hiong said...

Technology is about artifacts. Heh.

Bayman said...

nice. well put.