Wendell Lim's lab continues to lead the way in engineering synthetic cell-signaling pathways (not to mention lab website design). This time it's a Nature paper showing how modular protein-protein interaction domains can be swapped onto Rho guanine nucleotide exchange proteins to rewire morphological signaling pathways to respond to novel inputs.
Friday, July 27, 2007
Reprogramming Mammalian Cell Motility
Wendell Lim's lab continues to lead the way in engineering synthetic cell-signaling pathways (not to mention lab website design). This time it's a Nature paper showing how modular protein-protein interaction domains can be swapped onto Rho guanine nucleotide exchange proteins to rewire morphological signaling pathways to respond to novel inputs.
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Labels: cell motility, gtpase, guanine nucleotide exchange factors, Lim lab, morphology, rho, signaling, synthetic biology
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