Wednesday, January 21, 2009

siRNA cream for STDs

There is a small pharma company that is touting a new anti-herpes cream that protects against HSV-2 transmission. The cream contains two siRNAs: one targeted at nectin in the cells of the vaginal lining and the other UL29 in the viral genome. Nectin ko mice are resistant to HSV infection and UL29 is presumably vital for the virulence. The delivery is via a lipid system. Obviously this would be a nice approach to a number of viral STDs including AIDS. However I couldn't help but facepalm when I read the press release:

"As a new route to making better drugs, several companies have locked onto technology using small, interfering RNAs or siRNAs. These are molecules that can silence microRNAs -- tiny strands of RNA, or ribonucleic acid, that help turn genes into proteins."

Really... really?

But it makes we wonder, how long before we have an miRNA cream? They are, after all, bigger than siRNAs. Even bigger than p53.


Anonymous said...

Does this cream also provide lubrication?