Friday, July 21, 2006

Non-specific effects of DMSO

Speaking of noise: a lot of us use DMSO as a vehicle in TC to dissolve non-polar mollecules. Not suprisingly, DMSO affects a lot of things in a cell that can muddle the interpretation of data. It's commonly used as a differentiating agent for leukocytes, and is a known HDAC inhibitor, so beware...


1 comments:

Bayman said...

I think those problems are specific to ovarian cell lines. Maybe you should just try working with some real man's cells.