For those who like that kind of stuff, I found this excellent review on chromatin remodeling. It explains how both active and silent transcriptional information is maintained or changed during somatic differentiation but also meiotic progression. Meiotic progression is particularly interesting since in mammals meiosis is arrested for a long time, and after the oocyte has reached full size, it becomes completely transcriptionally silent. At the same time, the genome must be primed for fertilization, some genes must be imprinted, while for others the epigenetic information must be removed, and all this must be done by the 8 cell stage where the zygote initiates its own transcription.
Tuesday, June 05, 2007
Chromatin remodeling in the gonads
For those who like that kind of stuff, I found this excellent review on chromatin remodeling. It explains how both active and silent transcriptional information is maintained or changed during somatic differentiation but also meiotic progression. Meiotic progression is particularly interesting since in mammals meiosis is arrested for a long time, and after the oocyte has reached full size, it becomes completely transcriptionally silent. At the same time, the genome must be primed for fertilization, some genes must be imprinted, while for others the epigenetic information must be removed, and all this must be done by the 8 cell stage where the zygote initiates its own transcription.
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5 comments:
I would venture to say this is the greatest paper ever published.
It would be perfect, were it not for the lack of trojan horses.
Any calls from Hollywood for the movie rights yet?
Who's "Pepin D?" The first author should be "Coward A."
softcore perhaps
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