This month we have:
"METHODS TO IDENTIFY POLYNUCLEOTIDE AND POLYPEPTIDE SEQUENCES WHICH MAY BE ASSOCIATED WITH PHYSIOLOGICAL AND MEDICAL CONDITIONS"
Application number: 11/781,818
Filing date: Sep 12, 2007
Inventor: Walter Messier
Assignee: EVOLUTIONARY GENOMICS LLC
This invention describes a method for finding gene sequences responsible for the resistance of non-human primates, such as chimps, to diseases that afflict humans, such as HIV/AIDS, cancer and neurodegeneration. The method basically involves comparing genetic sequences from human and non-human primate species to determine which human disease genes have undergone evolution in primates since our lineages diverged. Information about these genes would then be used to design novel therapeutics. As an example, the inventors propose to determine how the gene encoding 17-beta-hydroxysteroid dehydrogenase has evolved in chimps to mediate cancer resistance.
CE7-SPECIFIC REDIRECTED IMMUNE CELLS
Application number: 11/849,643
Filing date: Sep 4, 2007
Inventor: Michael JENSEN
Assignee: CITY OF HOPE
This application describes how to engineer cytotoxic (cell-killing) immune cells that target a protein antigen specifically expressed on the surface of neuroblastoma tumor cells. An antibody against the neuroblastoma antigen is fused to the zeta chain of the T-cell receptor. This chimeric receptor can then be introduced into T cells, natural killer cells, neutrophils and macrophages so that they express it on their surface and thereby recognize and kill neuroblastoma cells.
"PORTABLE NMR DEVICE AND METHOD FOR MAKING AND USING THE SAME"
Application number: 11/851,291
Filing date: Sep 6, 2007
Inventors: Chang-Min Park, Shriram Ramanathan, Patrick Morrow, Kenneth Cadien
Assignee: INTEL CORPORATION
This one's pretty self-explanatory. NMR (nuclear magnetic resonance) technology is used in medicine for MRI imaging scans, as well as certain types of chemical analysis. This invention is describes a hand-held device that analyzes clinical DNA samples to perform disease diagnosis.
"TETRAPLOID WATERMELONS PRODUCING SMALL FRUITS"
Application number: 11/854,362
Filing date: Sep 12, 2007
Inventor: Xingping Zhang
Tetraploid watermelons are used to breed the triploid, seedless variety that we all love so much. This invention describes a way to make smaller, tastier tetraploid watermelon with a higher ratio of flesh-skin.
METHOD FOR DIAGNOSING IMMUNOLOGIC FOOD SENSITIVITY
Application number: 11/899,670
Filing date: Sep 7, 2007
Inventor: Kenneth D. Fine
This invention describes methods for diagnosing food allergies by determining whether the patient produces antibodies against commonly ingested foods. The approach is to collect fecal samples ( ie, "poop") and analyze it for the presence of antibodies against food antigens by ELISA. I would not want to be the poor sucker who works in this diagnostic lab:
"One method of concentrating the stool specimen is to spin the stool in a centrifuge to obtain a watery supernatant...Another method of concentrating the stool specimen, which is particularly used when the specimen is watery or diarrheal, is to freeze-dry or lyophilize the specimen to solid material and reconstituting it with water at a dry matter to water ratio equal to that of non-diarrheal stool".