There is of course differences when you compare moles and mass, as proteins like collagen are massive (>1000AA) compared to something like ubiquitin (<100AA). But looking at mass we can guess something like this...
- Collagen (25% of proteins)
- Actin (20% of dry muscle mass)
- Myosin? (second most abundent in muscle) or keratin (most abundent in epithelium/hair)?
- Albumin? (60% of serum protein,and only 40% of all albumin is present in serum)
- Superoxyde dismutase (most abundent in mitochondria)
- Hemoglobin? (95% of RBC dry mass)
- Osteocalcin (second most abundent in bones after collagen)
However, I have not given up on the idea that it should be a bacterial protein considering they have so much biomass, all to way to 2km down the crust and at the bottom of oceans. I would quote Stephen J Gould for this matter : "When one considers how deeply entrenched has been the dogma that most earthly biomass lies in the wood of our trees, this potentially greater weight of underground bacteria represents a major revision of conventional biology and quite a boost for the modal bacter. Not only does the Earth contain more bacterial organisms than all others combined (scarcely surprising, given their minimal size and mass); not only do bacteria live in more places and work in a greater variety of metabolic ways; not only did bacteria alone constitute the first half of life's history, with no slackening in diversity thereafter; but also, and most surprisingly, total bacterial biomass (even at such minimal weight per cell) may exceed all the rest of life combined, even forest trees, once we include the subterranean populations as well."
13 comments:
Give me a break. Everyone knows Stephen J Gould is full of it, as I clearly demonstrated by kicking his ass in the Darwin Wars...The real question is which gene is the most abundant on the Earth...
Bayman you plagaristic bastard, I was the one who kicked Stephen J Gould's ass, and I'm the one who wrote the selfish gene...Expect a phone call...my Oxford lawyers will be all over your ass.
Hmm, I'm surprised titin wasn't in there, especially if you're going by weight. It's not terribly abundant, but it's the largest known, and it's full name is the longest word in the English language, making it that much cooler at any rate.
“Titin, also called connectin, is the largest protein known and is the
third most abundant protein in striated muscle behind only myosin and
actin”
Oh man best scientist name ever... Bang et al. (2001) determined that the complete sequence of human titin encodes a 38,138-amino acid protein with a molecular mass of 4,200 kD.
I still think we should be measuring by number not mass! If I have 20 grapes and 3 grapefruits nobody is going to say the grapefruit is more abundant. Histones FTW!
while histones are smallish, as an octamer it gets to be quite large >100KDa. However a histone supposedly wins the record for the smallest protein-coding gene, mostly because it has no intron (~500bp). If you're looking for the smallest protein there are 54 predicted to be <100AA in the human genome. With the smallest ranking in at 54AA. If you take post-translational modeifications into account, then there are several hormonal peptide that are smaller...
I saw you talking about ubiquitin protein, so I thought you might be interested in Science Magazine's current webinar regarding disease treatment:
Science Magazine's Webinar: The Ubiquitin-Proteasome Pathway
Rubisco is the most abundant protein on earth. It is not found in humans because it relates to photosynthesis which only occurs in plants, but it is an enzyme (which are made of proteins).
Hi Friends,
The single most abundant protein in the human body is Collagen. It is mostly found in fibrous tissues such as tendon, ligament and skin, and is also abundant in bone, blood vessels, and intervertebral disc. Thanks a lot...
Hello,
The most abundant protein in the body is collagen. It makes up about ninety-percent of connective tissue. It is a major component in many tissues, especially bone, muscles, skin, blood vessels, and even the cornea of the eye. Thanks a lot for sharing with us...
The vast majority of resources state that it is collagen but I have never been able to track down a reference where the measurement is made. Most likely this statement comes from the 1800s when only a dozen or so proteinaceous substances were known. Modern biochemical approaches are available to definitively answer this question..
I am considering running the experiment and have been taking a poll on what people think it will be. There is a fair amount of data to support it isn't a collagen.
Benzoylmesaconine is the most abundant component of Wutou decoction, which is widely used in China because of its therapeutic effect on rheumatoid arthritis. Benzoylmesaconine
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