p53 restoration

We have discussed these papers in The Bay (where the baybs blab). But here's a nice summary of a few recent papers that describe the efficacy of reactivating p53 in cancer cells. Basically it works. Surprisingly despite ongoing selection for rapid replication cancer cells still contain sufficient protein networks that allow p53 to kill those misbehaving cells. The costs of activating p53 are likely increased senescence in normal cells.